It consists of stimulant drugs (mostly dopaminergic) to suppress daytime sleepiness and sleep attacks, antidepressants (mostly noradrenergic) for cataplexy and other REM-associated symptoms, occasionally hypnotics for disturbed night-time sleep and γ-hydroxybutyrate (GHB) for all three symptoms. Narcolepsy with cataplexy is the most severe example of sleepiness in human beings. Most studies suggest that the loss of hypocretin-containing neurons in NC might be attributable to an autoimmune process. Recent studies have shown that there is a marked decrease in hypocretin-1 levels in the cerebrospinal fluid (CSF) of patients with narcolepsy and a decrease in the number of hypocretin neurons in post-mortem brain tissues of narcolepsy subjects. The age at onset ranges from early childhood to 50–60 years of age with a bimodal distribution, including a large peak around 15 years and a smaller peak at approximately 36 years of age. Cataplexy is a partial or complete loss of muscle tone triggered by strong emotions. The main symptom is excessive daytime sleepiness, but patients can also develop abnormal rapid eye movement (REM) sleep manifestations including cataplexy, sleep paralysis and hypnagogic hallucinations. Narcolepsy with cataplexy (NC) is a rare sleep disorder. ▪ Describe treatments for NC likely to be available in the future as based on the review ▪ Describe current treatments for NC as based on the review ▪ Describe the clinical characteristics of narcolepsy with cataplexy (NC) as based on the review Upon completion of this activity, participants should be able to: Potential development of new wake-promoting drugs, anticataplectic medications, slow-wave sleep-enhancing treatments, hypocretin-replacement therapy and immunotherapy at early stages of the disease needs to be evaluated in the near future. The treatment of narcolepsy has evolved over the past few years with the widespread use of modafinil for daytime sleepiness, antidepressants for cataplexy and γ-hydroxybutyrate (sodium oxybate) for both symptoms. The cause of neural loss could be autoimmune since most patients have the human leukocyte antigen DQB1*0602 allele that predisposes individuals to NC. Pathophysiological studies have shown that NC is caused by the early loss of neurons in the hypothalamus that produce hypocretin/orexin, a wakefulness-associated neurotransmitter present in cerebrospinal fluid. In this article, we will describe the main symptoms and the current and future treatments of NC. Narcolepsy with cataplexy (NC) is a disabling orphan sleep disorder characterized by excessive daytime sleepiness, cataplexy and other dissociated manifestations of rapid eye movement sleep (hypnagogic hallucinations and sleep paralysis), as well as frequent movement and awakening during night-time sleep.
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I liked it both ways, but the north-facing room was very bright. I used Ammonite: it came out as a soft, true grey in both aspects, but it has a tiny amount of red in it, which stopped it from looking or feeling cold in the north-facing kitchen with a low ceiling.īy contrast, I painted a south-facing bedroom with Blackened, and it looked like a shade of white, but in a north-facing bedroom, it looked a pale, washed-out blue. I had a very open eco-home which had north and south facing aspects which had to be painted in the same colour. It all breaks up the uniform feel whereas if you do the whole thing it’s instantly calmer and larger. Think about painting a small room and how the wall are one colour and the door frames another, then you break for the window frames and the door. It’s also really calming because you’re not distracting the eye. It’s the way the Georgians did it – but you don’t have to have a Georgian house for this look. It will blur the edges of the room, make it look bigger and, crucially, show of your furnishings really well. Walls, woodwork and ceilings all in the same shade. The easy way, especially with the paler shades, is to take the gallery route. That will dramatically cut down the choices you have to make as there are several shades in each so you can find the two or three that work for you. Now, as I said earlier, it does make a different where you put these colours but as Joa Studholme, creative director of Farrow and Ball, says, you will be naturally drawn to one of these groups. Which isn’t me but this group includes Railings, Down Pipe and Pavilion Grey all of which feature strongly in my house. These are bluer than the others and will have a grittier feel that is suited to minimal living. 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There weren’t ‘out’ farmers in my community and there weren’t farming cooperatives.”ĭ was ready to start enacting their vision. “I wanted to be a part of something that was creating something different-an alternative to what I had experienced my whole life. When, during a stint working on the farm, they discovered the business was up for sale, Cheney could feel that there was a chance to answer those questions. “I kept asking, ‘How do we get different people in power? How we get queer people in power and try to create a farm that doesn’t harm the people who are employed there?’” Instead of backing down, Cheney studied at University of California, Santa Cruz, Center for Agroecology and Sustainable Food Systems, where they co-founded the first Queer Farmer Field Day. I was always attacked because of my gender identity and sexual orientation.” “My dad’s a farmer, I grew up just outside of Boston farming on and off my whole life.” That childhood experience constantly called them back to working the land, and yet, “It was a harmful journey to be a queer person in that world. I found my community.”Ĭheney’s journey was different. I had to know why Black and brown communities had less access to food and how to change it.” Once they started their journey, working in community gardening and educational projects like Farm School NYC, things changed. “I saw food disparities in the city I hadn’t ever seen living in NJ, and it was blatantly obvious. I worked jobs from construction and music production to restaurant work.” Nothing felt right until the move from the Jersey suburbs (where they were born and raised) to NYC generated a personal mission. “I barely graduated high school, I didn’t go to college. This year they received more than 316 applicants for the first year of their Pollinate queer farmer training program.įor co-founder D, finding where they truly felt a sense of belonging was not a simple path. It’s run on organic-farming tenets, with a sliding-scale CSA that serves both the local community and many parts of NYC it also works to generate safer spaces for queer and BIPOC (Black, Indigenous and People of Color) farmers to thrive. Rock Steady is queer* owned and operated cooperative vegetable farm rooted in social justice, food access, and farmer training. And that’s because Rock Steady Farm isn’t any old farm. The more than $100K loan they needed came from Seed Commons, a national community wealth cooperative. “Yeah, we started the business with $500 each and then we got the rest financed,” Cheney explains. The process that led up to that decision involved years of study, work, and determination by all the co-owners. “But we were, like, ‘Holy shit, this is an opportunity to take over an existing farm and turn it into something else, and the land is gorgeous.’” “It was a spur-of-the-moment opportunity, not planned-whatsoever!” says co-founder Maggie Cheney, leaning forward and explaining with their signature mix of energy and laser-like focus. Her recovery and her martial arts training inspire her dedication to multicultural body nurturance and community celebration.įor more information about Marcella's trainings, go to marcellaedtraining.The birth of Rock Steady Farm in Millerton was fast. She holds a second degree black belt and enjoys the exploratory path her training gives her. Marcella trains in Kajukenbo at Hand to Hand Kajukenbo Self Defense Center in Oakland. Marcella herself recovered from anorexia nervosa over 20 years ago. Marcella currently serves as a Licensed Clinical Psychologist (PSY # 27037) in Kaiser Permanente’s eating disorder clinic in Oakland and runs a private practice. She completed her post- doc internships at an eating disorder outpatient program and an eating disorder residential program for adolescents. Marcella’s desire to address eating disorders drove her to pursue her doctorate in clinical psychology, receiving her PhD in 2012. from UC Berkeley, and Master’s Degree in Public Health from the University of Michigan. and serves as Co-Chair of the Academy of Eating Disorders Diversity Equity and Inclusion committee. She is also on the Advisory Board for the Association of Size Health and Diversity (ASDAH), on the Advisory Board of Eating Disorder Recovery Support (EDRS) as Past President. Today she is on the About-Face Board of Founders and a consultant. In 1997, Marcella worked with About-Face, a nonprofit organization that addresses media impact on body image serving as the Director of Media Literacy until 2005. Marcella Raimondo, PhD, MPH is a passionate and spirited clinical trainer speaking from her heart on social justice and eating disorders since 1995. This point-against-point conception is opposed to "successive composition", where voices were written in an order with each new voice fitting into the whole so far constructed, which was previously assumed. In all cases the conception was probably what Margaret Bent calls "dyadic counterpoint", with each part being written generally against one other part, with all parts modified if needed in the end. Also, as opposed to the species terminology of counterpoint, polyphony was generally either "pitch-against-pitch" / "point-against-point" or "sustained-pitch" in one part with melismas of varying lengths in another. Baroque forms such as the fugue, which might be called polyphonic, are usually described instead as contrapuntal. Within the context of the Western musical tradition, the term is usually used to refer to music of the late Middle Ages and Renaissance. (16) This is a very respectable, 64-voice polyphonic synth featuring four oscillators.Polyphony In music, polyphony is a texture consisting of two or more simultaneous lines of independent melody, as opposed to music with just one voice or music with one dominant melodic voice accompanied by chords. (15) The device contains 8MB of RAM, a greyscale screen and a 16-channel polyphonic sound system. 182030 < Greek polyphnía variety of tones. representation of different sounds by the same letter or symbol. (14) The polyphonic sounds are for compatible Nokia, Ericsson, Motorola, NEC, Panasonic, Sharp and Siemens models and you need WAP to download them. a musical technique or style in which two or more melodic lines are in equitable juxtaposition. (13) The publication of polyphonic music, and particularly the Latin motets that Byrd insisted that East print, was not especially profitable. (12) The polyphonic voices of the poem remind us at every turn that all of these larger issues concern a pervasive discomfort with the body. It doesnt always mean several INDEPENDENT voices. Also, be clear over your definition of polyphony. (11) Meanings collide, conflict, merge, and diverge in the continuous multi-logic or polyphonic universe of the novel. Just look for homophonic and polyphonic elements in it. (10) When the Council of Trent inveighed against polyphonic music for sacred purposes, although the target of their arrows was Palestrina, they might just as well have been speaking of Gombert. (9) Using two iterations, I had nine polyphonic instruments up and running, with polyphony occasionally spilling over 100 notes simultaneously. (8) The way forward is to view texts as speaking with polyphonic voices and performing multiple speech actions. (7) The harp becomes the polyphonic instrument of choice as will be continually explained. (6) It didn't just have polyphonic sound, it had a colour screen, WAP, and was Java-enabled for downloadable games. (5) And in a Bakhtinian mode, she uses, in her more recent writings, polyphonic voices intermingling as an interface that brings out various jostling ideologies from various levels of psyche and history. (4) It has a 40-voice polyphonic sound system for ringtones, and operates on GSM and GPRS networks. (3) Take Johann Sebastian Bach's polyphonic masterpiece, The Art of the Fugue, add to it the modern technology of a computer-controlled piano, put it in the hands of a veteran concert pianist and this is the result. (2) This fissure is expressed by Glatshteyn's use of a polyphonic narrative style in which the autobiographical voice is muted while other voices predominate. (1) From the reader's point of view, this translation looks like a polyphonic swirl of voices. And with that, the BGS is retired as worse than the DWH. This means you can spec far more often, making up for the accuracy loss, allowing you to double spec on some corp kills, spec nearly every kill vs GWD bosses, etcetc. The second point is that the cost of the DWH's spec is 50% as opposed to the BGS's 65%. Whereas the DWH needs far lower stats to be very effective, only requiring a hit to do a massive defence drain. This is untrue in nearly all situations, save for max str gear on task, on a maxed account. Firstly, we've been assuming in all of these calculations that the BGS can hit an 80. But there are finally two major nails in the BGS's coffin. So where would you want to use the BGS in PvM? You can debatably use it at Bandos, assuming the accuracy is far lower on the DWH than I expect it will be. Vet'ion: Heavily in favour of crush, -10 crush, +200 slash. The DWH again destroys the BGS here, and of course, due to the high defence level of corp, the BGS scales even worse here. The same argument for Bandos goes for Zammy, though as he has a higher defence, the DWH scales better, and the BGS becomes even more ineffective.Ĭorp: In favour of crush, +100 crush, +200 slash. Though that said, Bandos' defence isn't tooo high, and assuming you miss 2x more often with the DWH, you'd still need 3 BGS specs to equal the effectiveness of 2 DWH specs. Lets take a look at the four main bosses the DWH and BGS are used against in turn again.īandos: equal slash and crush defence at +90. Looking back at the accuracy, we see that the DWH trumps the BGS's crush accuracy, meaning that the crush accuracy of the BGS is irrelevant against enemies that are weak to crush. Time to go back to the big sticker in the argument, where we've been assuming BGS and DWH have the same accuracy. (assuming anyone 4mans Bandos at the point everyone can spec 80s with BGS, and also assuming Graador's health could even take 4 80s without dying.) You'll see that the BGS lags behind severely in the number of specs to be on par with the DWH's def drain - to the point at which the kill would be over by the time you've commited at best 4 people's specs to the kill. Something to note is that the damage dealt by these attacks will be consistently higher with the BGS by approximately 10 points on average. Number of specs for BGS to be better(20%)-4-5-9-6 Number of specs for BGS to be better(30%)-6-7-10-8 Just for comparison's sake, I've also added a 20% drain row, to show a proposed nerf which I thought of. I've never done Vetion, but I'll add their stats in too. The only other possible example I can think about would be Sara? Maybe? Or perhaps Vetion. Now, these def drain weapons are primarily used against Graador (Bandos), Kril (Zammy), and Corp. That would mean the average spec would drain defence by 40. How good is 30% def drain compared to a BGS spec? Lets assume that the bgs can hit an 80, being incredibly generous. So, lets at first assume the attack hits, ignoring accuracy. +Def drain equal to hit-+30% drain if hits (Unless you're scum crashing at Bandos.) But how good exactly does the DWH compare to its obvious counterpart, the BGS?īGS-DWH+Dragon Defender PvM is clearly where this weapon will shine, nobody uses a BGS in PvP as burst is more important, and nobody uses an AGS in PvM, as the def drain is more important. So lets just say, for pvp, this weapon is fairly balanced. This is a great sidegrade to ags, as it won't hit as high, but will drain your opponent's defence by at least 30. The damage is a nice bonus, and considering that the dragon warhammer's strength bonus is on par with that of the abyssal tentacle(+85 vs +86 respectively), in a PvP scenario, it will be like multiplying your ab.tent by 1.3x, which (in rune fights) will easily allow hits reaching 60 - higher in bandos etc, as well as the defence drain. The spec of the dragon warhammer costs 50% energy, increases the damage dealt by 30%, and drains the target's defence by 30% of their current level. The only significant upside to the dragon warhammer is obviously it's special attack. That said, it will still be the new BiS (best in slot) one handed crush weapon - not that said title holds any merit. This is because of the warhammer's slow attack speed in comparison to the scimitar. It's a one handed crush weapon, with relatively mediocre stats, so I'm going to ignore it as a dps weapon, when d scim will likely have relatively similar sustained damage. I'd like to talk about why I personally voted no on the dragon warhammer, and why Jagex seriously need to improve in testing items.įirstly, lets talk about the dragon warhammer. You’ll also see her trying to dig deep to discover Android gaming’s most hidden gems. Nowadays, you’ll find Faith studying spreadsheets and assembling data to theorycraft new teams and builds for Genshin Impact. Now with her analytical mindset, passion for writing, and core identity as a gamer, she can finally chase her dreams as a technical writer and gaming journalist. on the NES she has owned over 15 devices for gaming ranging from handhelds to consoles. I am not sharing analytics and using the cloud for photo syncing with the Photos app. I do not understand why it is taking so fricking long to backup to my hard drive. My iPhone is plugged in directly to the back of my iMac with the cable that came with my iPhone 7. She’s also been a gamer for over 20 years, starting with Super Mario Bros. I have a 1TB hard drive and 300GB of free space available. Faith’s first Android phone was Samsung Galaxy Note II in 2012, giving her a taste of how a small piece of powerful hardware can open anyone up to endless opportunities for your favorite hobbies. Her favorite pastime was writing reports, presentations, tutorials, and literature reviews, which led to her pursuing a career in writing after completing a graduate certificate in technical writing. Before joining Android Police, Faith studied Chemistry and graduated with an honors specialization in Chemistry in 2016 leading her to spending many hours toiling around the lab during her time spent as an undergraduate, eventually developing her analytical mindset to dissect and dissemble information and data to arrive at an answer. Her area of expertise is in action RPGs and gacha games, but will play and study the occasional competitive shooter. You’ll find her writing about the newest free-to-play game to hit Android, or compiling explainer guides on popular social networking apps like Twitch and Discord. Faith writes guides, how-tos, and roundups on the latest Android games and apps for Android Police. it is making me think of replacing my iMac with a PC laptop instead of a MacBook if I cannot get this to work right because I do not have time for this! Did I need to import and then delete the camera roll before syncing the photos to iCloud? If so - why wouldn't Apple have told me to do that in the Photos/icloud setup? I cannot delete any photos from my phone now without deleting them from everywhere. I did not delete camera roll when I changed to uploading my photos to iCloud (which was done in late June). I thought it would be better with the 7 after replacing my 6 in June 2017, iCloud setup was no problem but the computer backup has been intolerably slow. I don't get what is slowing it down, but I have had this problem with my previous iPhone 6 and it has just gotten progressively worse. I have a 1TB hard drive and 300GB of free space available. I understand why a backup might take an hour, maybe - but an entire day is unacceptable to expect someone to do frequently enough to protect their data. I have an iPhone 7 with 256GB of storage, and am using about half of that for music, movies, photos (whatever is automatically put there with the iCloud sync), and apps. I do not understand why there would be any problem with a backup when iTunes is not backing up my photos anymore. I am using the Photos app and am storing my photos in iCloud, so I do not have a camera roll album to delete photos from manually. If an application is corrupt, doesn't Apple have a way to detect that and update the application? They cannot expect anyone to spend that kind of time to fix this problem! It does not take that long to backup to iCloud, so why should it take that long to backup to my computer?ĭo not tell me I have to delete every single application and then reload one by one! That is WAY too much time to spend and there has to be another fix. I also do not want to trust iCloud for all backups, I want to also backup to my computer. I backup to iCloud every night automatically, but I need a computer backup to use an app to extract my messages and notes to PDF. This is ridiculous! I have searched online and can only find solutions that are 5+ years old or for iCloud backups. I am trying to backup to my computer again and the estimated time in iTunes is 10 hours. I have a prior backup from a week ago that took 9 hours to finish. You can do this by running the "javac" command in the command prompt or terminal. Compile Java code: Once you have written your Java code, you need to compile it into byte code using the Java compiler.Write Java code: Next, write Java code using any text editor or integrated development environment (IDE) like Eclipse, NetBeans, or IntelliJ IDEA.Install JRE: First, you need to download and install the latest version of JRE from the official Java website or FileHorse.Deployment: It provides an easy and convenient way to deploy Java programs on various platforms, such as desktops, servers, and mobile devices.Internationalization: It provides support for internationalization and localization, which allows Java programs to run in different languages and regions.Platform Independence: Java programs that run on JRE are platform-independent, which means that they can run on any platform that has JRE installed, regardless of the underlying hardware or operating system.Automatic Memory Management: It includes automatic memory management, which means that the JVM automatically manages the allocation and deallocation of memory for Java programs.It includes features such as sandboxing, code signing, and permission-based access control. Security: It provides a robust security model that ensures that Java programs run in a secure environment. These libraries include collections, I/O, networking, security, and many other features. Class Libraries: It includes a set of class libraries that provide a wide range of functionality for Java programs.Java Virtual Machine (JVM): JRE includes a Java Virtual Machine (JVM), which is responsible for executing Java bytecode.It's the platform for launching careers, exploring human-to-digital interfaces, architecting the world's best applications, and unlocking innovation everywhere-from garages to global organizations. From laptops to datacenters, game consoles to scientific supercomputers, cell phones to the Internet, Java is everywhere! It is at the heart of the digital lifestyle. The program is fast, secure, and reliable. There are lots of applications and websites that will not work unless you have Java installed, and more are created every day. If you don't have an account you can use the links on the top of this page to learn more about it and register for one for free.įor current Java releases, please consult the Oracle Software Download page.It is a programming language and computing platform first released by Sun Microsystems in 1995. Only developers and Enterprise administrators should download these releases.ĭownloading these releases requires an account. Java SE 8u211 and later updates are available, under the Java SE OTN License.įor production use Oracle recommends downloading the latest JDK and JRE versions and allowing auto-update. These Java SE 8 update releases are provided under the Binary Code License (“BCL”). They are not updated with the latest security patches and are not recommended for use in production. WARNING: These older versions of the JRE and JDK are provided to help developers debug issues in older systems. 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Playing cooperatively is a treat because at that point, you’re into the experience for at least thirty bucks, but it’s definitely much more fun with a partner. With quick reflexes and good accuracy, anyone can have fun. It’s tough, but it doesn’t force players to memorize enemy locations. I really enjoy light gun games, and Lethal Enforcers seems to be one of the genre’s better examples. This scene played like an episode of The Flintstones – my friend and I saw, like, thirty National Rubber Stamp Companies. The game has five stages and I’m sure this continues to be the case throughout the game. We eventually managed this, but the second level, a trip to Chinatown, upped the difficulty, while also asking us to have even better accuracy. It was easy to complete the first level, a bank robbery, and even do so without losing lives, but to unlock the next level, we had to have 70% accuracy. My friend and I had a rough go at the game. I imagine the Super Nintendo version is identical to the Genesis version, although without playing it myself, I can’t say with certainty. Both games looked identical, although the Sega CD version should look much better than its Genesis counterpart. My friend and I played the Genesis and Sega CD versions of Lethal Enforcers and I only noticed one difference between the two versions – the soundtrack of the Sega CD version was of a higher quality. While that sounded like an ad, that’s pretty much the best way I can sum up the game. Once those qualities are on lock-down though, you might just be able to make your city a little cleaner. Without quick timing and precise accuracy, game over comes quickly. You’ll shoot through scenes in which bad guys pop their heads up from cover looking to blow yours off. Crime is being committed and as a cop, it’s your (and your partner’s) duty to uphold the law. Lethal Enforcers contains little narrative, but little is needed. The Genesis and Sega CD versions were very grainy. Enabling cooperative play is the harder to find pink light gun, although it works across all three platforms. Developed and published by Konami, each version came bundled with the Konami Justifier, a blue light gun modeled after the Cult Python, the iconic. It was originally released as an arcade game in 1992, but was ported to the Genesis, Super Nintendo, and Sega CD from 1993-1994. One game with a big presence back then was Lethal Enforcers. The genre wasn’t as ubiquitous on home consoles, but it seems like each console from back in the day had a light gun. On consoles, Lethal Enforcers was released in a massive cardboard box that could contain the Konami Justifier.īack when arcades ruled the video game roost, light gun games were widespread. |
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